The Brain/Gut connection in PD
Even since the first description of Parkinson’s disease (PD) by Dr. Parkinson himself in 1817, we have known the gastrointestinal (GI) tract to be particularly involved in this condition. However, only until recently have scientists and physicians re-prioritized the GI manifestations of PD. Increasing evidence suggests that PD may actually originate in the gut of some patients, and we have an improved understanding of the connection of GI functions with drug absorption and potentially motor symptoms.
Common GI manifestations in PD
• Slow transit constipation
• Defecatory disorders
• Delayed gastric emptying
• Poor absorption of levodopa
• Bloating
• Small intestinal bacterial overgrowth
• Weight loss
• Difficult swallowing
• Fecal incontinence/leakage/soiling
For many Parkinson’s patients, the GI manifestations are much more significant drivers of quality of life than the classic motor symptoms, Unfortunately, most gastroenterologists are not familiar with the unique issues in this group, such as PD medications, dietary issues, and PD-related GI dysmotility.
Physician
Dr. El-Nachef is a physician-scientist who is a board-certified gastroenterologist with a clinical focus on neurogastroenterology and GI motility disorders. While on faculty at UCLA, Dr. El-Nachef founded a clinic exclusively dedicated to patients with Parkinson’s disease suffering from gastrointestinal issues.